Field of Research

Pharmacology, Molecular biology, Cytoskeleton, Cell adhesion, Cell polarity, Neuronal development, Atherosclerotic diseases, Psychiatric disorders

Selected Publications
  • Nakayama, M.;Goto, T. M.;Sugimoto, M.;Nishimura, T.;Shinagawa, T.;Ohno, S.;Amano, M.;Kaibuchi, K. Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev. Cell. 14, 2008, 205-15.

  • Nishimura, T.;Kaibuchi, K. Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev. Cell. 13, 2007, 15-28.

  • Qadota, H.;Inoue, M.;Hikita, T.;Koppen, M.;Hardin, J. D.;Amano, M.;Moerman, D. G.;Kaibuchi, K. Establishment of a tissue-specific RNAi system in C. elegans. Gene. 400, 2007, 166-173.

  • Sugimoto, M.;Nakayama, M.;Goto, T. M.;Amano, M.;Komori, K.;Kaibuchi, K. Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells. Biochem. Biophys. Res. Commun. 361, 2007, 462-67.

  • Takefuji, M.;Mori, K.;Morita, Y.;Arimura, N.;Nishimura, T.;Nakayama, M.;Hoshino, M.;Iwamatsu, A.;Murohara, T.;Kaibuchi, K.;Amano, M. Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. Biochem. Biophys. Res. Commun. 355, 2007, 788-94.

  • Brandt, D. T.;Marion, S.;Griffiths, G.;Watanabe, T.;Kaibuchi, K.;Grosse, R. Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J. Cell Biol. 178, 2007, 193-200.

  • Ishizuka, K.;Chen, J.;Taya, S.;Li, W.;Millar, J. K.;Xu, Y.;Clapcote, S. J.;Hookway, C.;Morita, M.;Kamiya, A.;Tomoda, T.;Lipska, B. K.;Roder, J. C.;Pletnikov, M.;Porteous, D.;Silva, A. J.;Cannon, T. D.;Kaibuchi, K.;Brandon, N. J.;Weinberger, D. R.;Sawa, A. Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. Mol. Psychiatry. 12, 2007, 897-99.

  • Mishima, M.;Maesaki, R.;Kasa, M.;Watanabe, T.;Fukata, M.;Kaibuchi, K.;Hakoshima, T. Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc. Natl. Acad. Sci. U. S. A. 104, 2007, 10346-51.

  • Otsuji, M.;Ishihara, S.;Co, C.;Kaibuchi, K.;Mochizuki, A.;Kuroda, S. A mass conserved reaction-diffusion system captures properties of cell polarity. PLoS. Comput. Biol. 3, 2007, e108.

  • Patrakitkomjorn, S.;Kobayashi, D.;Morikawa, T.;Wilson, M. M.;Tsubota, N.;Irie, A.;Ozawa, T.;Aoki, M.;Arimura, N.;Kaibuchi, K.;Saya, H.;Araki, N. Neurofibromatosis Type 1 (NF1) Tumor Suppressor, Neurofibromin, Regulates the Neuronal Differentiation of PC12 Cells via Its Associating Protein, CRMP-2. J. Biol. Chem. 283, 2008, 9399-413.

  • Qadota, H.;Mercer, K. B.;Miller, R. K.;Kaibuchi, K.;Benian, G. M. Two LIM Domain Proteins and UNC-96 Link UNC-97/PINCH to Myosin Thick Filaments in Caenorhabditis elegans Muscle. Mol. Biol. Cell. 2007, 4317-26.

  • Yagita, Y.;Kitagawa, K.;Sasaki, T.;Terasaki, Y.;Todo, K.;Omura-Matsuoka, E.;Kaibuchi, K.;Hori, M. Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia. J. Neurosci. Res. 85, 2007, 2460-69.

  • Yamamoto, M.;Ramirez, S. H.;Sato, S.;Kiyota, T.;Cerny, R. L.;Kaibuchi, K.;Persidsky, Y.;Ikezu, T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am. J. Pathol. 172, 2008, 521-33.

  • Arimura, N. and Kaibuchi, K. Neuronal polarity: from extracellular signals to intaracellular mechanism. Nat Rev Neurosci, 8 (3), 194-205. (2007)

  • Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., and Kaibuchi, K. GSK-3b regulates phosphorylation of CRMP-2 and neuronal polarity. Cell, 120 (1), 137-149. (2005)

  • Nishimura, T., Yamaguchi, T., Kato, K., Yoshizawa, M., Nabeshima, Y. I., Ohno, S., Hoshino, M., and Kaibuchi, K. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol, 7 (3), 270-277. (2005)

  • Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F., and Kaibuchi, K. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell, 109 (7), 873-885. (2002)

  • Inagaki, N., Chihara, K., Arimura, N., Menager, C., Kawano, Y., Matsuo, N., Nishimura, T., Amano, M., and Kaibuchi, K. CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci, 4 (8), 781-782. (2001)

  • Fukata, M., and Kaibuchi, K. Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol, 2 (12), 887-897. (2001)

  • *Kaibuchi, K., Kuroda, S., and Amano, M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem, 68, 459-486. (1999)

  • Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K., Nakamura, T., Ookubo, T., Izawa, I., Nagase, T., Nomura, N., Tani, H., Shoji, I., Matsuura, Y., Yonehara, S., and Kaibuchi, K. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science, 281 (5378), 832-835. (1998)

  • Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y., and Kaibuchi, K. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science, 275 (5304), 1308-1311. (1997)

  • Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science, 273 (5272), 245-258. (1996)