Field of Research

Natural Product Chemistry, Bioorganic Chemistry

1) Characterization of venom components of solitary wasp, which paralyze spiders

2) Total synthesis of biologically active natural products

3) Design of biologically active multi-valent polymers

Selected Publications
  • Mild Conditions for Cyclization of b-Triketides to the Corresponding g-Pyrones Carrying Adjacent Chiral Centers toward Biomimetic Synthesis of Fully Substituted g-Pyrone-containing Natural Products, Arimoto, H.; Nishiyama, S.; Yamamura, S. Tetrahedron Lett. 1990, 31, 5619-5620.
  • Vallartanone B; Synthesis and Related Studies, Arimoto, H.; Yokoyama, R.; Nakamura, K.; Okumura, Y.; Uemura, D. Tetrahedron 1996, 44, 13901-13908.
  • Total Synthesis of Allixin; An Anti-tumor promoter from Garlic, Arimoto, H.; Asano, S.; Uemura, D. Tetrahedron Lett. 1997, 38, 7761-7762.
  • Absolute Stereochemistry of Halichlorine; A potent inhibitor of VCAM-1 Induction, Arimoto, H.; Hayakawa, I.; Kuramoto, M.; Uemura, D. Tetrahedron Lett. 1998, 39, 861-862.
  • Anomalous Epoxide Formation Upon Wittig Olefination With 1-Iodoethyl Triphenylphosphonium Ylide, Arimoto, H.; Kaufman, M. D.; Kobayashi, K.; Qiu, Y.; Smith, III, A. B. Synlett 1998, 7, 765-768.
  • Synthesis of Pinnaic acid; Asymmetric Construction of Spirocyclic Core, Arimoto, H.; Asano, S.; Uemura, D. Tetrahedron Lett. 1999, 40, 3583-3586.
  • Multi-valent polymer of vancomycin: Enhanced antibacterial activity against VRE, Arimoto, H.; Nishimura, K.; Kinumi, T.; Hayakawa, I.; Uemura, D. J. Chem. Soc., Chem. Commun., 1999, 1361-1362.
  • Evolution of a gram-scale synthesis of (+)-discodermolide, Smith, A. B., III; Beauchamp, T. J.; LaMarche, M. J.; Kaufman, M. D.; Qiu, Y.; Arimoto, H.; Jones, D. R.; Kobayashi, K. J. Am. Chem. Soc. 2000, 122, 8654-8664.
  • Affinity of a Vancomycin-polymer with Bacterial Surface Models, Arimoto, H.; Oishi, T.; Nishijima, M.; Kinumi, T. Tetrahedron Lett. 2001, 42, 3347-3350.
  • Synthesis of (})-Pinnaic acid, Hayakawa, I.; Arimoto, H.; Uemura, D. Heterocycles, 2003, 59, in press.