Field of Research

Biochemistry, Molecular biological, Glycobiology. Main projects involve biological analyses of the heparin-binding growth factor midkine, the Ig superfamily member basigin and the glycosaminoglycan keratan sulfate in the nervous system, cancer and inflammation.
Selected Publications

  • Ishimoto, T., Takei, Y. Yuzawa, Y., Hanai, K., Nagahara, S., Tarumi, Y., Matsuo, S., Kadomatsu, K. Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates Hapten-induced contact hypersensitivity. Mol. Ther. 16, 387-395, 2008

  • Takei, Y., Nemoto, T., Mu, P., Fujishima, T., Ishimoto, T., Hayakawa, Y., Yuzawa, Y., Matsuo, S., Muramatsu, T., Kadomatsu, K. In vivo silencing of a molecular target by short interfering RNA electroporation: Tumor vascularization correlates to delivery efficiency. Mol. Cancer Ther. 7, 211-221, 2008

  • Narita, H., Chen, S., Komori, K., Kadomatsu, K. Midkine is expressed by infiltrating macrophages in in-stent restenosis in hypercholesterolemic rabbits. J. Vas. Surg. In press.

  • Liu, D., Kobayashi, T., Onishi, A., Furusawa, T., Iwamoto, M., Suzuki, S., Miwa, Y., Nagasaka, T., Maruyama, S., Kadomatsu, K., Uchida, K., Nakao, A. Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for Xenotransplantation. Xenotransplantation. 14, 67-73, 2007.

  • Hidaka, H., Hiroshi Yagasaki, H. Takahashi, Y., Hama, A., Nishio, N., Makito Tanaka, M, Yoshida, N., Villalobos, I.B., Wang, Y., Xu. Y.Y., Horibe, K., Chen, S., Kadomatsu, K., Kojima, S., Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia. Leukemia Res. 31, 1053-1059, 2007.

  • Maehara, H., Kaname, T., Yanagi, K., Hanzawa, H., Owan, I., Kinjou, T., Kadomatsu, K., Ikematsu, S., Iwamasa, T., Kanaya, F., Naritomi, K.. Midkine as a novel target for antibody therapy in osteosarcoma. Biochem Biophys Res Commun. 358, 757-762, 2007

  • Kobayashi, T., Liu, D., Ogawa, H., Miwa, Y., Nagasaka, T., Maruyama, S., Li, Y.T., Onishi, A., Kuzuya, T., Kadomatsu, K., Uchida, K., Nakao, A. Alternative Strategy for Overcoming ABO Incompatibility. Transplantation 83, 1284-1286, 2007

  • Kosugi, T., Yuzawa, Y., Sato, W., Kato, N., Arata-Kawai, H., Matsuo, S., Kadomatsu. K. Midkine is involved in tubulo-interstitial inflammation associated with diabetic nephropathy. Lab. Invest. 87, 903-913 (2007).

  • Chen, S., Bu, G., Takei, Y., Sakamoto, K., Ikematsu, S., Muramatsu, T., Kadomatsu, K. Midkine and LDL receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells. J. Cell Sci. 120, 4009-4015, 2007.

  • Ishiguro, K., Ando, T., Maeda, O., Ohmiya, N., Niwa, Y., Kadomatsu, K., Goto, H. Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochem. Biophys. Res. Commun. 362, 218-223 (2007).

  • Kadomatsu, K. Keratan sulfate and gliosis. In gNeural Proteoglycansh (Editor: Maeda, N.) Research Signpost. 2007.

  • Kosugi, T., Yuzawa, Y., Sato, W., Kawai, H., Matsuo, S., Takei, Y., Muramatsu, T., Kadomatsu, K. Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Am. J. Pathol. 168, 9-19 (2006).

  • Zhang, H., Muramatsu, T., Murase, A., Yuasa, S., Uchimura, K., Kadomatsu, K. N-acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury. Glycobiology 16, 702-710 (2006).

  • Zhang, H., Uchimura, K., Kadomatsu, K. Brain keratan sulfate and glial scar formation. Ann. NY Acad. Sci. 1086:81-90 (2006). Review.

  • Kawashima, H., Petryniak, B., Hiraoka, N., Mitoma, J., Huckaby, V., Nakayama, J., Uchimura, K. Kadomatsu, K., Muramatsu, T., Lowe, J.B., Fukuda, M. N-Acetylglucosamine-6-O-sulfotransferase-1 and -2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Nat. Immunol. 6, 1096-1104 (2005).

  • Suzuki, N., Shibata, Y., Urano, T., Murohara, T., Muramatsu, T., Kadomatsu, K. Proteasomal degradation of the nuclear targeting growth factor midkine. J. Biol. Chem. 279, 17785-17791 (2004).

  • Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S, Muramatsu, T. A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res. 64, 3365-3370 (2004).

  • Shibata, Y., Muramatsu, T., Hirai, M., Inui, T., Kimura, T., Saito, H., Lynn M. McCormick, L.M., Bu, G., Kadomatsu, K. Nuclear targeting by the growth factor midkine. Mol. Cell. Biol. 22, 6788-6796 (2002).

  • Uchimura, K., Kadomatsu, K., Nishimura, H., Muramatsu, H., Nakamura, E., Kurosawa, N., Habuchi, O., El-Fasakhany, F.M., Yoshikai, Y., Muramatsu, T. Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development and oversulfated chondroitin sulfates. J. Biol. Chem. 277, 1443-50 (2002).

  • Qi, M., Ikematsu, S., Maeda, N., Ichihara-Tanaka, K., Sakuma, S., Noda, M., Muramatsu, T., Kadomatsu, K. Haptotactic migration induced by midkine: Involvement of protein-tyrosine phosphatase z, mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J. Biol. Chem. 276, 15868-15875 (2001).

  • Horiba, M., Kadomatsu, K., Nakamura, E., Muramatsu, H., Ikematsu, S., Sakuma, S., Hayashi, K., Yuzawa, Y., Matsuo, S., Kuzuya, M., Kaname, T., Hirai, M., Siato, H., Muramatsu, T. Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J. Clin. Invest. 105, 489-495 (2000).

  • Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q.-W., Miyauchi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, M., Taguchi, O., Yamamura, K., Arimura, K., Muramatsu, T. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev. Biol. 194, 152-165 (1998).

  •  Kadomatsu, K.,* Hsin, A.Y., Bonham, M.J., Danielpour, D. Regulation of apoptosis induced by TGF-b1 in non-tumorigenic and tumorigenic rat prostatic epithelial cell lines. Cancer Res. 56, 5146-5149 (1996). (*The first two authors equally contributed to this work).

  • Kadomatsu, K., Anzano, M.A., Slayter, M.V., Winokur, T.S., Smith, J.M., Sporn, M.B. Expression of sulfated glycoprotein 2 is associated with carcinogenesis induced by N-nitroso-N-methylurea in rat prostate and seminal vesicle. Cancer Res. 53, 1480-1483 (1993).

  • Kadomatsu, K., Huang, R-P., Suganuma, T., Murata, F., Muramatsu, T. A retinoic acid responsive gene, MK, found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embyogenesis. J. Cell Biol. 110, 607-616 (1990).