分子生物学

1膜輸送系の分子機構

2イオンチャネル・トランスポーターの構造と機能

3膜電位センサーの形成機構

4植物の環境ストレス適応反応

• Matsuda, N., Kobayashi, H., Katoh, H., Ogawa, T., Futatsugi, L., Nakamura, T., Bakker, E.P., and Uozumi, N.　Na⁺-dependent K⁺ uptake Ktr system from the cyanobacterium Synechocystis sp. PCC 6803 and its role in the early phases of cell adaptation to hyperosmotic shock.,J. Biol. Chem., Inpress
  

• Zhang, L., Lee, J-K., John, S. A., Uozumi, N., and Kodama, I., Mechanosensitivity of GIRK channels is mediated by PKC-dependent channel-PIP₂ interaction.,J. Biol. Chem., 279, 7037 - 7047. (2004)
  
  
• Sato, Y., Sakaguchi, M., Goshima, S., Nakamura, T., and Uozumi, N.,Molecular dissection of the contribution of negatively and positively charged residues in S2, S3, and S4 to the final membrane topology of the voltage sensor in the K⁺ channel, KAT1.,J. Biol. Chem., 278, 13227-13234. (2003)
  
  
• Umigai, N., Sato, Y., Mizutani, A., Utsumi, T., Sakaguchi, M., and Uozumi, N. ,Topogenesis of two transmembrane type K⁺ channels, Kir 2.1 and KcsA.,J. Biol. Chem., 278, 40373-40384. (2003)
  
  
• Berthomieu, P., Conejero G., Nublat A., Brackenbury W.L. Lambert C., Savio, C., Uozumi, N., Oiki, S., Yamada, K., Cellier, F., Gosti, F., Simonneau, T., Essah, P. A., Tester, M., Very, A-A, Sentenac, H., and Casse, F.,Functional analysis of AtHKT1 in Arabidopsis shows that Na⁺ recirculation by the phloem is crucial for salt tolerance.,EMBO J., 22, 2004-2014. (2003)
  
  
• Holtmann, G., Bakker, E. P., Uozumi, N., and Bremerl, E.,KtrAB and KtrCD: two K⁺ uptake systems in Bacillus subtilis and their role in the adaptation to hypertonicity.,J Bacteriol., 185, 1289-1298. (2003)
  
  
• Sato, Y., Sakaguchi, M., Goshima, S., Nakamura, T., and Uozumi, N.,Integration of Shaker-type K⁺ channel, KAT1 into the endoplasmic reticulum membrane: Synergistic insertion of voltage sensing segments, S3-S4 and independent insertion of pore-forming segments, S5-P-S6.,Proc. Natl. Acad. Sci. USA., 99, 60-65. (2002)
  
  
• Maser, P., Hosoo, Y., Goshima, S., Horie, T., Eckelman B., Yamada, K.,Yoshida, K., Bakker, E.P., Shinmyo, A., Oiki, S., Schroeder, J. I., and Uozumi, N.,Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants.,Proc. Natl. Acad. Sci. USA., 99, 6428-6433. (2002)
  
  
• Kato, Y., Sakaguchi, M., Mori, Y., Saito, K., Nakamura, T., Bakker, E. P., Sato, Y., Goshima, S., and Uozumi, N.,Evidence in support of a four transmembrane-pore-transmembrane topology model for the Arabidopsis thaliana Na⁺/K⁺ translocating AtHKT1 protein, a member of the superfamily of K⁺ transporters.,Proc. Natl. Acad. Sci. USA., 98, 6488-6493. (2001)
  
  
• Nakamura, T., Fujisaki, Y., Enomoto, H., Nakayama, Y., Takabe, T., Yamaguchi, N., and Uozumi, N.,Residue aspartate-147 from the third transmembrane region of Na⁺/H⁺ antiporter NhaB of Vibrio aliginolyticus plays a role in its activity.,J. Bacteriol., 183, 5762-5767. (2001)