Natural products chemistry
1. Isolation, structure, and synthesis of antitumor natural products
 2. Chemistry of the super-carbon-chain compounds
 3. Bioactive metabolites from marine dinoflagellate

• M. Kita, M. C. Roy, E. R. O. Siwu, I. Noma, T. Takiguchi, M. Itoh, K. Yamada, T. Koyama, T. Iwashita, D. Uemura, Durinskiol A: A Long Carbon-Chain Polyol Compound from the Symbiotic Dinoflagellate Durinskia sp. Tetrahedron Lett., 48, 3423-3427 (2007).

• M. Kita, M. C. Roy, E. R. O. Siwu, I. Noma, T. Takiguchi, K. Yamada, T. Koyama, T. Iwashita, A. Wakamiya, D. Uemura, Relative Stereochemistries of the Ether Rings and Sugar Moieties in Durinskiol A. Tetrahedron Lett. 2007, 48, 3429-3432.

• T. Sengoku, D. Uemura, H, Arimoto, Ring-closing Metathesis Approach to a 16-Memberd Macrocycle of Kendomycin, Chem. Lett. 2007, 36, 726-727.

• T. Ito, M. Ito, H. Arimoto, H. Takamura, D. Uemura, Studies toward the Total Synthesis of Nakiterpiosin: Construction of the CDE Ring System by a Transannular Diels-Alder Strategy, Tetrahedron Lett. 2007, 48, 5465-5469.

• K. Shimokawa, H. Takamura, D. Uemura, Concise Synthesis of a Highly Functionalized Cyclopentane Segment: Toward the Total Synthesis of Kansuinine A, Tetrahedron Lett. 2007, 48, 5623-5625.

• K. Shimokawa, K. Yamada, M. Kita, Uemura, D. Convergent Synthesis and in Vivo Inhibitory Effect on Fat Accumulation of (-)-Ternatin, a Highly N-Methylated Cyclic Peptide, Bioorg. Med. Chem. Lett. 2007, 17, 4447-4449.

• S. Xu, H. Arimoto, D. Uemura, Asymmetric Total Synthesis of Pinnaic Acid, Angew. Chem. Int. Ed. 2007, 46, 5746-5749.

• H. Suzuki, N.S. Aly, Y. Wataya, H.S. Kim, I. Tamai, M. Kita, D. Uemura, Preparation of Quinoline Hexose Analogs as Novel Chloroquine-Resistant Malaria Treatments (1). Synthesis of 4-Hydroxyquinoline-b-glucosides, Chem Pharm Bull (Tokyo). 2007, 55, 821-824.

• K. Shimokawa, I. Mashima, A. Asai, T. Ohno, K. Yamada, M. Kita, D. Uemura, Biological activity, structural features, and synthetic studies of (-)-ternatin, a potent fat-accumulation inhibitor of 3T3-L1 adipocytes. Chem Asian J. 2008, 3, 438-446.

• M. Kita, R. Miwa, T. Widianti, Y. Ozaki, S. Aoyama, K. Yamada, D. Uemura, Revised structure of kasarin, an antibacterial pyrazinone compound from the marine microorganism Hyphomycetes sp. Tetrahedron Letters, 2007, 48, 8628-8631

• E. R. O. Siwu, O. Ohno, M. Kita, D. Uemura, Durinskiol B: A New Durinskiol Congener from the Symbiotic Marine Dinoflagellate Durinskia sp. Chem. Lett. 37, (2008) 236-237

• K. Shimokawa, Y. Iwase, K. Yamada, D. Uemura, Synthesis and inhibitory effect on fat accumulation of (-)-ternatin derivatives modified in the b-OH-D-Leu7 moiety, Org. Biomol. Chem., in press

• O. Ohno, M. Ye, T. Koyama, K. Yazawa, E. Mura, H. Matsumoto, T. Ichino, K. Yamada, K. Nakamura, T. Ohno, K. Yamaguchi, J. Ishida, A. Fukamizu, D. Uemura, Inhibitory Effects of Benzyl Benzoate and Its Derivatives on Angiotensin II-Induced Hypertension. Bioorg Med Chem., in press

• Kitamura, M.; Koyama, T.; Nakano, Y.; Uemura, D.
  Characterization of A Natural Inducer of Coral Larval Metamorphosis. 
  J. Exp. Mar. Biol. Ecol. 340, 96-102, 2007.

• Yamamoto, T.; Arimoto, H.; Kinumi, T.; Oba, Y.; Uemura D.
  Identification of Proteins from Venom of the Paralytic Spider Wasp, Cyphononyx dorsalis. 
  Insect Biochem. Mol. Biol. 37, 278-286, 2007.

• Inuzuka, T.; Fujisawa, T.; Arimoto, H.; Uemura, D.
  Molecular Shape of Palytoxin in Aqueous Solution.
  Org. Biomol. Chem. 5, 897-899, 2007.

• Kita, M.; Ohishi, N.; Konishi, K.; Kondo, M.; Koyama, T.; Kitamura, M.; Yamada, K.; Uemura, D.
  Symbiodinolide, a Novel Polyol Macrolide That Activates N-Type Ca²⁺ Channel from the Symbiotic Dinoflagellate Symbiodinium sp.
  Tetrahedron in press.

• Blarina Toxin, A Mammalian Lethal Venom from the Short-tailed Shrew Blarina brevicauda: Isolation and Characterization, M. Kita, Y. Nakamura, Y. Okumura, S. D. Ohdachi, Y. Oba, M. Yoshikuni, H. Kido, and D. Uemura, Proc. Natl. Acad. Sci. U.S.A. 101, 7542-7547 (2004).

• Symbioimine Exhibiting Inhibitory Effect of Osteoclast Differentiation, from the Symbiotic Marine Dinoflagellate Symbiodinium sp., M. Kita, M. Kondo, T. Koyama, K. Yamada, T. Matsumoto, K. -H. Lee, J. -T. Woo, and D. Uemura, J. Am. Chem. Soc. 126, 4794-4795 (2004).

• Enantioselective Synthesis of the Spirotetracyclic Carbon Core of Mangicols using a Stereoselective Transannular Diels-Alder Strategy, K. Araki, K. Saito, H. Arimoto, and D. Uemura, Angew. Chem. Int. Engl., 43, 81-84 (2004).

• Nakiterpiosin, A Novel Cytotoxic C-Nor-D-Homosteroid from the Okinawan Sponge Terpios hoshinota, T. Teruya, S. Nakagawa, T. Koyama, K. Suenaga, M. Kita and D. Uemura, Tetrahedron Lett. 44, 5171-5173 (2003).

• Channel Induction by Palytoxin in Yeast Cells Expressing Na⁺,K⁺-ATPase or Its Chimera with Sarco/endoplasmic Reticulum Ca²⁺-ATPase, K. Ito, I. Toyoda, M. Higashiyama, D. Uemura, M. H. Sato, S. H. Yoshimura, T. Ishii and K. Takeyasu, FEBS Lett. 543, 108-112 (2003).

• Arachidonic Acid and a-Linolenic Acid, Feeding Attractants for the Crown-of-Thorns Sea Star Acanthaster planci, from the Sea Urchin Toxopneustes pileolus, T. Teruya, K. Suenaga, T. Koyama, Y. Nakano, and D. Uemura, J. Exp. Mar. Biol. Ecol. 266, 123-134 (2001).

• Structural Determination of Pteriatoxins A, B and C, Extremely Potent Toxins from the Bivalve Pteria penguin, N. Takada, N. Umemura, K. Suenaga, and D. Uemura, Tetrahedron Lett., 42, 3495-3497 (2001).

• Pinnatoxins B and C, the Most Toxic Compounds in the Pinnatoxin Series from the Okinawan Bivalve Pinna muricata, N. Takada, N. Umemura, K. Suenaga, T. Chou, A. Nagatsu, T. Haino, K. Yamada, and D. Uemura, Tetrahedron Lett., 42, 3491-3494 (2001).

• Pinnatoxin A: A Toxic Amphoteric Macrocycle from the Okinawan Bivalve Pinna muricata, D. Uemura, T. Chou, T. Haino, A. Nagatsu, S. Fukuzawa, S-Z. Zheng, and H-S. Chen, J. Am. Chem. Soc., 117, 1155-1156 (1995).

• Norhalichondrin A, an Antitumor Polyether Macrolide from a Marine Sponge, D. Uemura, K. Takahashi, T. Yamamoto, Y. Okumura, C.Katayama, J. Tanaka, and Y. Hirata, J. Am. Chem. Soc., 107, 4796-4798 (1985).

• Stereochemistry of Palytoxin. 4. Complete Structure, J. K. Cha, W. J. Christ, J. M. Finan, H. Fujioka, Y. Kishi, L. L. Klein, S. S. Ko, J. Leder, W. W. McWhorter, Jr., K. -P. Pfaff, M. Yonaga, D. Uemura, and Y. Hirata, J. Am. Chem. Soc., 104, 7369-7371 (1982).