理論生物物理学、化学物理学。特に

１）蛋白質フォールディングと構造、デザイン

２）蛋白質および蛋白質複合体のダイナミクスと機能

３）遺伝子スイッチとそのネットワーク

４）液体の遅い緩和、液体の水における水素結合ネットワークの理論

• M. Sasai, “Energy Landscape Picture of Supercooled Liquids: Application of a Generalized Random Energy Model”, J. Chem. Phys. 118, 10651-10662, (2003).
  
  

• M. Sasai and P. G. Wolynes, “Stochastic Gene Expression as a Many Body Problem”, Proc. Natl. Acad. Sci. USA, 100, 2374-2379 (2003).
  
  
• T.P. Terada, M. Sasai, and T. Yomo, “Conformational Change of Actomyosin Complex drives the multiple stepping movement”, Proc. Natl. Acad. Sci. USA, 99, 9202-9206 (2002).
  
  
• J. Higo, M. Sasai, H. Shirai, H. Nakamura, and T. Kugimiya, “Large Vortex-like Structure of Dipole Field in Computer Models of Liquid Water and Dipole-bridge Between Biomolecules”, Proc. Natl. Acad. Sci. USA, 98, 5961-5964 (2001).
  
  
• T. Yomo, S. Saito, and M. Sasai, “Gradual Development of Protein-like Global Structures through Functional Selection”, Nature Structural Biology, 6, 743-746 (1999).
  
  
• S. Saito, M. Sasai, and T. Yomo, “Evolution of the Folding Ability of Proteins through Functional Selection”, Proc. Natl. Acad. Sci. USA, 94, 11324-11328 (1997).
  
  
• M. Sasai, “Conformation, Energy, and Folding Ability of Selected Amino Acid Sequences”, Proc. Natl. Acad. Sci. USA, 92, 8438-8442 (1995).
  
  
• M. Sasai, I. Ohmine and R. Ramaswamy, “Long Time Fluctuation of Liquid Water -1/f spectrum of energy fluctuation in hydrogen bond network rearrangement dynamics-”, J. Chem. Phys, 96, No.4, 3045-3053 (1992).
  
  
• M. Sasai, “Instabilities of Hydrogen Bond Network in Liquid Water”, J. Chem. Phys. 93, 7329-7341 (1990).
  
  
• J. Takimoto and M. Sasai, “Excited States and Their Relaxation Dynamics in trans-Polyacetylene”, Phys. Rev. B 39, 8511-8524 (1989).