Theoretical biological and chemical physics, especially on

1) Protein folding, structure and design,

2) Function and dynamics of proteins and protein complexes,

3) Gene switches and their networks,

4) Structure and dynamics of liquid water and other supercooled liquids.

• M. Sasai, “Energy Landscape Picture of Supercooled Liquids: Application of a Generalized Random Energy Model”, J. Chem. Phys. 118, 10651-10662, (2003).
  
  

• M. Sasai and P. G. Wolynes, “Stochastic Gene Expression as a Many Body Problem”, Proc. Natl. Acad. Sci. USA, 100, 2374-2379 (2003).
  
  
• T.P. Terada, M. Sasai, and T. Yomo, “Conformational Change of Actomyosin Complex drives the multiple stepping movement”, Proc. Natl. Acad. Sci. USA, 99, 9202-9206 (2002).
  
  
• J. Higo, M. Sasai, H. Shirai, H. Nakamura, and T. Kugimiya, “Large Vortex-like Structure of Dipole Field in Computer Models of Liquid Water and Dipole-bridge Between Biomolecules”, Proc. Natl. Acad. Sci. USA, 98, 5961-5964 (2001).
  
  
• T. Yomo, S. Saito, and M. Sasai, “Gradual Development of Protein-like Global Structures through Functional Selection”, Nature Structural Biology, 6, 743-746 (1999).
  
  
• S. Saito, M. Sasai, and T. Yomo, “Evolution of the Folding Ability of Proteins through Functional Selection”, Proc. Natl. Acad. Sci. USA, 94, 11324-11328 (1997).
  
  
• M. Sasai, “Conformation, Energy, and Folding Ability of Selected Amino Acid Sequences”, Proc. Natl. Acad. Sci. USA, 92, 8438-8442 (1995).
  
  
• M. Sasai, I. Ohmine and R. Ramaswamy, “Long Time Fluctuation of Liquid Water -1/f spectrum of energy fluctuation in hydrogen bond network rearrangement dynamics-”, J. Chem. Phys, 96, No.4, 3045-3053 (1992).
  
  
• M. Sasai, “Instabilities of Hydrogen Bond Network in Liquid Water”, J. Chem. Phys. 93, 7329-7341 (1990).
  
  
• J. Takimoto and M. Sasai, “Excited States and Their Relaxation Dynamics in trans-Polyacetylene”, Phys. Rev. B 39, 8511-8524 (1989).